Fumaric acid #CAS110-17-8

CAS Number:110-17-8

Chemical Formula:C4H4O4

  • Synonyms:

    • TRANS-BUTENEDICARBOXYLIC ACID

    • TRANS-BUTENEDIOIC ACID

    • TRANS-1,2-ETHYLENEDICARBOXYLIC ACID

      Appearance:White Fine Crystalline Powder

    MOQ (Minimum Order Quantity): 1 FCL (Full Container Load)



Product Details

Fumaric acid #CAS110-17-8

  1. Fumaric acid is an important kind of organic chemical raw materials as well as the intermediate of fine chemical products. Meanwhile, it is also an important kind of derivatives of maleic anhydride, being widely used in food, coatings, resins and plasticizers. In the food industry, fumaric acid, used as souring agent, can be applied to soft drinks, western-style wine, cold drinks, fruit juice concentrate, canned fruit, pickles and ice cream. As an acidic substance used as solid beverage gas production agent, it has excellent bubble durability with delicate product organization.

  2. Fumaric acid has been used as a food acidulant since 1946. As a food additive, it is used as an acidity regulator and can be denoted by the E number E297. Chemically it is an unsaturated dicarbonic acid and is part of the citric acid cycle.

  3. Fumaric acid is a common food additive included in many processed foods to keep them stable and to add tartness. The substance has a more sour flavor than citric acid, another common food additive. Fumaric acid occurs naturally in fumitory, bolete mushrooms, lichen and Iceland moss. As an additive, fumaric acid is produced synthetically, mainly from malic acid from apples. Fumaric acid as an additive is regulated under the Codex Alimentarius General Standard for Food Additives (GSFA), a collection of internationally recognized standards.The U.S. Food and Drug Administration considers it safe.

Application of Fumaric acid

🍜 Main Uses in Food

Fumaric acid is primarily used as an acidity regulator and sourdough agent. It is permitted for use in many foods, with strict maximum usage limits.

It can be used in chewing gum, bread, pastries, biscuits, fresh wet dough products (such as noodles and dumpling wrappers), fruit and vegetable juices, carbonated beverages, cured meat products, sausages, and other foods, in appropriate amounts as needed for production.

Besides being a sourdough agent, its acidity also plays a role in inhibiting bacteria and preserving food to some extent. In some regions, it is also permitted for use in winemaking to control malolactic fermentation.

🏭 Other Industrial and Pharmaceutical Uses

Chemical Raw Material: It is an important raw material for manufacturing unsaturated polyester resins, alkyd resins, and adhesives.

Pharmaceutical Field: In the pharmaceutical industry, it can be used to produce the antidote dimercaptosuccinic acid and ferrous fumarate (an iron supplement used to treat iron deficiency anemia).

Treatment of psoriasis: In Germany, fumarate is the first-line oral treatment for severe psoriasis.

Production Processes of Fumaric acid

  1. Chemical Synthesis (Mainstream): Using petroleum-based benzene or n-butane as raw materials, the mixture is first oxidized to maleic anhydride, then hydrolyzed and heated (isomerized) to obtain fumaric acid. Advantages include mature technology and high yield; disadvantages include reliance on petroleum resources.

  2. Biofermentation (Green Direction): Utilizing microorganisms such as Rhizopus to convert glucose or biomass such as straw into fumaric acid. Advantages include renewable raw materials, but current production costs and efficiency are not as high as the chemical method.

  3. Enzyme Catalysis (Specific Applications): Using specific enzymes to directly convert L-malic acid to fumaric acid. Product purity is high, but raw material costs are high; used for specific product production.

Fumaric acid Chemical Properties
Melting point 298-300 °C (subl.) (lit.)
Boiling point 137.07°C (rough estimate)
density 1.62
vapor pressure 1.7 mm Hg ( 165 °C)
refractive index 1.5260 (estimate)
FEMA 2488 | FUMARIC ACID
Fp 230 °C
storage temp. Store below +30°C.
solubility 95% ethanol: soluble0.46g/10 mL, clear, colorless
form Fine Crystalline Powder
pka3.02, 4.38(at 25℃)
color White
PH3.19(1 mM solution);2.57(10 mM solution);2.03(100 mM solution);
Odorodorless
Odor Typeodorless
biological sourcesynthetic
explosive limit40%
Water Solubility 0.63 g/100 mL (25 ºC)
Merck 14,4287
JECFA Number618
BRN 605763
Stability:Stable at room temperature. Decomposes at around 230 C. Incompatible with strong oxidizing agents, bases, reducing agents. Combustible.
Cosmetics Ingredients FunctionsBUFFERING
Cosmetic Ingredient Review (CIR)Fumaric acid (110-17-8)
InChI1S/C4H4O4/c5-3(6)1-2-4(7)8/h1-2H,(H,5,6)(H,7,8)/b2-1+
InChIKeyVZCYOOQTPOCHFL-OWOJBTEDSA-N
SMILESOC(=O)\C=C\C(O)=O
LogP-4.02 at 20℃
CAS DataBase Reference110-17-8(CAS DataBase Reference)
NIST Chemistry ReferenceFumaric acid(110-17-8)
EPA Substance Registry SystemFumaric acid (110-17-8)

Safety Information
Hazard Codes Xi
Risk Statements 36
Safety Statements 26
RIDADR UN 9126
WGK Germany 1
RTECS LS9625000
Autoignition Temperature375 °C
TSCA TSCA listed
HS Code 29171900
Storage Class11 - Combustible Solids
Hazard ClassificationsEye Irrit. 2
Hazardous Substances Data110-17-8(Hazardous Substances Data)
ToxicityLD50 orally in Rabbit: 9300 mg/kg LD50 dermal Rabbit 20000 mg/kg

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