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Vitamin B12 CAS：68-19-9

Vitamin B12 (VB12)： frequently referred to as cobalamin, represents a distinct category within the B-complex vitamins. Structurally, it is the most intricate vitamin molecule identified to date, characterized as a complex organic compound featuring a central trivalent cobalt ion situated within a guanidine ring analogous to porphyrin. Uniquely among vitamins, it incorporates a metal ion, and its physical manifestation as red crystals has led to the moniker "red vitamin." Since plants are incapable of synthesizing or containing VB12, primary dietary sources include liver, milk, meat, eggs, and fish. Biologically, VB12 functions as an indispensable coenzyme for the biosynthesis of ribonucleic acid and deoxyribonucleic acid. Insufficient levels of this vitamin can precipitate severe neurological disorders, including peripheral neuropathy and central encephalopathy.

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Product Details

Vitamin B12：It also commonly referred to as cobalamin, belongs to the B-complex vitamins and consists of a series of cobalt-containing corrin-type complex organic substances. At the core of its corrin macrocyclic structure lies a trivalent cobalt ion, which shares structural similarities with the porphyrin ring system.

Among all known vitamins, cobalamin boasts the largest molecular size and the most sophisticated chemical structure, and it is also the only vitamin that incorporates a metal element within its molecular framework. Its crystal presents a red color, hence it is also known as the “red vitamin”.

Unlike animals, plants are unable to synthesize or accumulate vitamin B12 naturally. Animal liver is the richest natural source of this vitamin, while abundant amounts can also be found in milk and dairy products, meat, eggs and various fish foods.

Vitamin B12 CAS：68-19-9

Melting point	>300°C
alpha	23656 -59 ± 9° (dil aq soln)
Boiling point	>300 °C
bulk density	450-600kg/m3
Fp	9℃
storage temp.	2-8°C
solubility	Sparingly soluble in water and in ethanol (96 per cent), practically insoluble in acetone. The anhydrous substance is very hygroscopic.
pka	pKa 3.28±0.04(H2O,D2O t=23±0.5 Iunspeci?ed) (Uncertain)
form	Crystalline Powder or Crystals
color	Red to dark red
Odor	dark red cryst. or powd., odorless and tasteless
PH	6.0 (20°C, 1g/L in H2O)
biological source	synthetic ((organic))
Water Solubility	Soluble
Sensitive	Hygroscopic
Merck	1410014
BRN	4122889
Exposure limits	NIOSH: IDLH 25 mg/m3
Stability:	Hygroscopic. Keep cold and dry.
InChIKey	RMRCNWBMXRMIRW-WZHZPDAFSA-L
LogP	3.570 (est)
EPA Substance Registry System	Vitamin B12 (68-19-9)
Safety Information
Hazard Codes
HS Code	2936260000
Hazardous Substances Data	68-19-9(Hazardous Substances Data)
Toxicity	LD50 intravenous in mouse: 2gm/kg

Vitamin B12 CAS：68-19-9

As an indispensable enzyme cofactor, vitamin B12 takes part in the synthetic processes of RNA and DNA. A lack of this nutrient is likely to trigger nervous system lesions involving the peripheral and central nerves.

These natural cobalt-coordinated compounds are structurally built on the corrinoid skeleton. Differences in the molecular structure of vitamin B12 derivatives depend solely on the β-ligand bound to the central cobalt atom, and such homologs are collectively named cobalamins.

Commercial manufacturing of vitamin B12 mainly adopts microbial fermentation biosynthesis. Its major dietary origins include fish, meat, animal liver and dairy products, whereas plant foods barely contain any cobalamin.

Methylcobalamin and adenosylcobalamin both act as vital coenzymes in vivo and can be metabolically transformed into physiologically active configurations. Severe vitamin B12 insufficiency commonly leads to megaloblastic anemia and progressive neurological impairment.

Vitamin B12 CAS：68-19-9