Tetramethylguanidine #CAS80-70-6
CAS Number：80-70-6
Synonyms:
Guanidine, N,N,N',N'-tetramethyl-
1,1,3,3-Tetramethyl Guanidine (TMG)
N,N,N,N-Tetramethy1 Guanidine
Appearance: APHA: ≤150 Liquid
MOQ (Minimum Order Quantity): 1 FCL (Full Container Load)
Tetramethylguanidine #CAS80-70-6
N,N,N',N' -Tetramethylguanidine (TMG) [80-70-6], C5H13N3, Mr 115.18, is a stable, unusually strong base, pKa 13.6 (25 ℃), with a free imino group. It is a colorless to light-yellow liquid, miscible with water and common organic solvents: 0.92 g/cm3 (25 ℃), bp 160 ℃, vapor pressure 0.03 kPa (25℃).
Application of Tetramethylguanidine
Tetramethylguanidine (TMG) is used as polyurethane foam catalyst, as accelerator for the syntheses of polysulfured rubber, as a strong base in the photochemical (e.g. couplers) and in the pharmaceutical (e.g. steroids) industries. Product Data Sheet
Base employed in the preparation of alkyl nitriles from alkyl halides and 3′-alkylthymidines from 3′-nitrothymidines.
1,1,3,3-Tetaramethylguanidine is used as a strong, non-nucleophilic base for alkylations in organic synthesis. 1,1,3,3-Tetramethylguanidine is an efficient and selective catalyst for the benzoylation of alcohols.
| Tetramethylguanidine Chemical Properties |
| Melting point | -30 °C |
| Boiling point | 162-163 °C (lit.) |
| density | 0.916 g/mL at 20 °C (lit.) |
| vapor pressure | 0.2 mm Hg ( 20 °C) |
| refractive index | n |
| Fp | 140 °F |
| storage temp. | Store below +30°C. |
| solubility | Acetonitrile (Slightly), DMSO (Slightly), Methanol (Slightly) |
| pka | 15.20±0.70(Predicted) |
| form | Liquid |
| color | APHA: ≤150 |
| PH | 12.7 (10g/l, H2O, 25℃) |
| Relative polarity | 5.5 |
| Odor | mild ammoniacal odor |
| explosive limit | 1.0-7.5%(V) |
| Water Solubility | miscible |
| Sensitive | Air Sensitive |
| BRN | 969608 |
| Dielectric constant | 23.100000000000001 |
| Stability: | Stable. Combustible. Incompatible with strong oxidizing agents, mineral and organic acids, carbon dioxide. Air-sensitive. |
| InChI | 1S/C5H13N3/c1-7(2)5(6)8(3)4/h6H,1-4H3 |
| InChIKey | KYVBNYUBXIEUFW-UHFFFAOYSA-N |
| SMILES | CN(C)C(=N)N(C)C |
| LogP | -0.49 at 20℃ |
| CAS DataBase Reference | 80-70-6(CAS DataBase Reference) |
| NIST Chemistry Reference | N,N,N',N'-Tetramethylguanidine(80-70-6) |
| EPA Substance Registry System | Guanidine, N,N,N',N'-tetramethyl- (80-70-6) |
| Safety Information |
| Hazard Codes | C |
| Risk Statements | 22-34-20/22-10 |
| Safety Statements | 26-27-36/37/39-45-16 |
| RIDADR | UN 2920 8/PG 2 |
| WGK Germany | 1 |
| F | 9-23 |
| Autoignition Temperature | 222 °C |
| Hazard Note | Harmful/Corrosive |
| TSCA | TSCA listed |
| HazardClass | 8 |
| PackingGroup | II |
| HS Code | 29252000 |
| Storage Class | 3 - Flammable liquids |
| Hazard Classifications | Acute Tox. 4 Oral Eye Dam. 1 Flam. Liq. 3 Met. Corr. 1 Skin Corr. 1B |
| Toxicity | LD50 orally in Rabbit: 835 mg/kg |
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