Allantoin #CAS97-59-6
CAS Number:97-59-6
Chemical Formula: C4H6N4O3
Synonyms:
(2,5-dioxo-4-imidazolidinyl)urea
ALLANTOIN
5-UREIDOHYDANTOIN
Appearance:White Powder
MOQ (Minimum Order Quantity): 1 FCL (Full Container Load)
Allantoin #CAS97-59-6
Allantoin, an imidazole heterocyclic compound, is a derivative of uric acid and a naturally occurring component of human skin. Uric acid, acting as an antioxidant, reacts with free radicals to produce allantoin. It was first extracted by Mollster in 1912 from the underground stem of *Chemicalbook*, a plant in the Boraginaceae family. Allantoin promotes cell and tissue growth, metabolism, and softens keratin. These properties are particularly pronounced when applied to ulcerated and suppurating skin, thus accelerating wound healing and making it an excellent active agent for treating skin injuries.
Allantoin was once known as an anti-irritant, effectively reducing the irritation of irritants. It is also an antioxidant; like some other water-soluble vitamins, its ability to scavenge free radicals is similar to that of vitamin *Chemicalbook*, thus enhancing the antioxidant capacity of cells. Therefore, the US Food and Drug Administration (FDA) classifies it as a Category 1 highly active skin care agent, as it is non-toxic, non-irritating, and does not cause allergic reactions.
Application of Allantoin
1. Allantoin can promote skin cell growth and rapid wound healing. Used as anti-ulcer drug, mixed with dry aluminum hydroxide gel, for gastrointestinal ulcers and inflammation. The product can soften keratin, making the skin retain moisture, moist and soft, is special effects of additive in cosmetic. Allantoin and its derivatives are the quality improver and additive of many household chemical products. Allantoin protein may be formulated anti-irritant, anti-dandruff, cleaning and wound healing scalp preparations, making hair soft, shiny and elastic. The product is an amphoteric compound, can bind to a variety of material form double salts, with dark, antiseptic, analgesic, deodorant, anti-oxidation effect, and therefore is household chemical products, additives of cosmetics such as freckle cream, acne solution, shampoo , soap, toothpaste, shaving lotion, convergence liquid and antiperspirant deodorant detergent. Allantoin also is a biochemical reagents.
2. For the roles such as skin care, oral products, anti-allergy, the treatment of skin ulcers promote wound healing.
3. Widely used in treatment of a variety of skin ulcers and trauma and additives of nutritional cosmetics.
| Allantoin Chemical Properties |
| Melting point | 230 °C (dec.) (lit.) |
| Boiling point | 283.17°C (rough estimate) |
| density | 1.6031 (rough estimate) |
| refractive index | 1.8500 (estimate) |
| Fp | 230-234°C |
| storage temp. | 2-8°C |
| solubility | H2O: soluble0.1g/10 mL, clear, colorless |
| form | Powder |
| pka | 8.96(at 25℃) |
| color | White |
| Odor | odorless, tasteless |
| Water Solubility | Slightly soluble in water. Freely soluble in alkalis |
| Decomposition | 230-234 ºC |
| Merck | 14,258 |
| BRN | 102364 |
| Henry's Law Constant | 2.9×1012 mol/(m3Pa) at 25℃, HSDB (2015) |
| Stability: | Stable. Incompatible with strong oxidizing agents. |
| Cosmetics Ingredients Functions | SOOTHING SKIN PROTECTING SKIN CONDITIONING |
| Cosmetic Ingredient Review (CIR) | Allantoin (97-59-6) |
| InChI | 1S/C4H6N4O3/c5-3(10)6-1-2(9)8-4(11)7-1/h1H,(H3,5,6,10)(H2,7,8,9,11) |
| InChIKey | POJWUDADGALRAB-UHFFFAOYSA-N |
| SMILES | NC(=O)NC1NC(=O)NC1=O |
| LogP | -2.26 at 20℃ |
| CAS DataBase Reference | 97-59-6(CAS DataBase Reference) |
| NIST Chemistry Reference | Urea, (2,5-dioxo-4-imidazolidinyl)-(97-59-6) |
| EPA Substance Registry System | Allantoin (97-59-6) |
| Safety Information |
| Hazard Codes | Xn,Xi |
| Risk Statements | 22-36/37/38 |
| Safety Statements | 22-24/25-36-26 |
| WGK Germany | 1 |
| RTECS | YT1600000 |
| TSCA | TSCA listed |
| HS Code | 29332100 |
| Storage Class | 11 - Combustible Solids |
| Hazardous Substances Data | 97-59-6(Hazardous Substances Data) |
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