Procaine hydrochloride #CAS 51-05-8
CAS Number：51-05-8
Synonyms:
TIMTEC-BB SBB001081
bernocaine
isocaine-asid
Appearance: Colorless To White Crystals Or Crystalline Powder
MOQ (Minimum Order Quantity): 1 FCL (Full Container Load)
Procaine hydrochloride #CAS51-05-8
Procaine hydrochloride, also called Novocain, or Novocaine, a topical anesthetic, which can block the nerve fiber conduction temporarilyand has a narcotic effect,strong effect, low toxicity, and non-addictive, but on the skin, mucosal penetration is weak, unsuitable for surface anesthesia, patients are used for infiltration, conduction and spinal anesthesia.
The structure of procaine hydrochloride with aromatic primary amino, easy oxidation discoloration pH, temperature, UV, oxygen and metal ions can accelerate the oxidation discoloration. The aqueous solution was stable in pH3.0~5. So preparation of procaine hydrochloride injection, it generally takes add acid to regulate pH 3.3 to 5.5, and strictly control the sterilization temperature and time. to 100 ℃ steam sterilization 30min circulation is appropriate, and should pay attention to shading, sealed save.
The above information is edited by the chemicalbook of Kui Xiongfeng.
Procaine hydrochloride is a white crystalline, odorless powder that is freely soluble in water, but less soluble in alcohol and almost insoluble in ether; solutions acid to litmus. Because the ester bond in the structure can be hydrolyzed to produce p-aminobenzoic acid and diethylaminoethanol, under certain conditions, p-aminobenzoic acid can be further decarboxylated to produce toxic aniline. Procaine hydrochloride has aromatic primary amino groups in its structure, which can be easily oxidized and discolored. pH, temperature, ultraviolet light, oxygen and metal ions can accelerate the oxidation and discoloration.
Application of Procaine hydrochloride
Procaine hydrochloride has been used as a component of Krebs Henseleit buffer for incubating the left ventricular cardiac tissue in its resting length. It has also been used as an inducer in M9 media for induction assay. It is a sodium channel blocker and DNA methylation inhibitor.
Procaine is a local anesthetic of the amino ester group that is primarily used as a topical anesthetic. Procaine is also used to control the pain of intramuscular injection of penicillin as well as in dentistry.
| Procaine hydrochloride Chemical Properties |
| Melting point | 155-156 °C(lit.) |
| Boiling point | 195-196°C 17mm |
| density | 1.1761 (rough estimate) |
| refractive index | 1.5270 (estimate) |
| Fp | 195-196°C/17mm |
| storage temp. | 2-8°C |
| solubility | DMF: 20 mg/ml DMSO: 14 mg/ml Ethanol: 16 mg/mlPBS (pH 7.2): 10 mg/ml |
| form | Crystals or Crystalline Powder |
| color | Colorless to white |
| Water Solubility | soluble |
| Sensitive | Air Sensitive |
| Merck | 14,7757 |
| BRN | 3917802 |
| Stability: | Stable. Incompatible with strong oxidizing agents. |
| InChI | 1S/C13H20N2O2.ClH/c1-3-15(4-2)9-10-17-13(16)11-5-7-12(14)8-6-11;/h5-8H,3-4,9-10,14H2,1-2H3;1H |
| InChIKey | HCBIBCJNVBAKAB-UHFFFAOYSA-N |
| SMILES | Cl.CCN(CC)CCOC(=O)c1ccc(N)cc1 |
| LogP | 2.364 (est) |
| CAS DataBase Reference | 51-05-8(CAS DataBase Reference) |
| EPA Substance Registry System | Procaine hydrochloride (51-05-8) |
| Safety Information |
| Hazard Codes | T |
| Risk Statements | 25-43-36/37/38-23/24/25 |
| Safety Statements | 36/37/39-45-37/39-26 |
| RIDADR | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | DG2275000 |
| TSCA | TSCA listed |
| HazardClass | 6.1 |
| PackingGroup | III |
| HS Code | 29242990 |
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
| Hazard Classifications | Acute Tox. 3 Oral Skin Sens. 1 |
| Toxicity | LD50 in mice (mg/kg): 660 ± 60 s.c. (Goldenthal) |
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