1-Tetralone #CAS529-34-0
It is a white crystalline powder at low temperatures. Odorless, with a sour taste, easily soluble in water and ethanol, insoluble in chloroform. Density 1.096, melting point 5-6°C, boiling point 127°C (13 mmHg), refractive index 1.5675-1.5695, flash point 130°C, water soluble. Used in the synthesis and preparation of various chiral food additives and nutritional additives, such as the resolution process of novel functional nutritional additive L-carnitine and certain chiral drugs. Also used in beverages, candies, bread, and gelatin as an acidulant, biochemical reagent, racemic compound resolving agent, and pharmaceutical resolving agent. It is also used in photography, canning, printing and dyeing, ceramics, and in the preparation of other resolving agents and salts, esters, and pharmaceutical intermediates. It is also an intermediate for various drugs (contraceptives, rodenticides), and is used as a solvent and plastic softener.
Application of 1-Tetralone
Pharmaceutical synthesis: It is a key structural precursor for the synthesis of various antidepressants (such as sertraline hydrochloride) and antitumor drugs. Agricultural chemicals: It serves as a starting material for agricultural fungicides, herbicides, and other pesticide products. Materials industry: It plays an important role in the research and development and production of liquid crystal materials.
1-Tetralone is a reagent used in the synthesis of amino-pyrazolopyridines with anti-NF-κB and pro-apoptotic potential.
| 1-Tetralone Basic information |
| Product Name: | 1-Tetralone |
| Synonyms: | KETOTETRAHYDRONAPHTHALENE;1,2,3,4-TETRAHYDRO-1-NAPHTHALENONE;1-TETRALONE;3,4-DIHYDRO-2H-NAPHTHALEN-1-ONE;3,4-DIHYDRO-1-(2H)NAPHTHALENEONE;1(2H)-Naphthalenone;1,2,3,4-Tetrahydro-1-oxonaphthalene;1-Tetralone,97% |
| CAS: | 529-34-0 |
| MF: | C10H10O |
| MW: | 146.19 |
| EINECS: | 208-460-6 |
| Product Categories: | Bioactive Small Molecules;Building Blocks;C10;Carbonyl Compounds;Cell Biology;Chemical Synthesis;Ketones;Organic Building Blocks;T;PHARMACEUTICAL INTERMEDIATES;pharmaceutical;Cardiovascular & Blood System Agents;bc0001;529-34-0 |
| Mol File: | 529-34-0.mol |
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| 1-Tetralone Chemical Properties |
| Melting point | 2-7 °C(lit.) |
| Boiling point | 113-116 °C6 mm Hg(lit.) |
| density | 1.099 g/mL at 25 °C(lit.) |
| refractive index | n |
| Fp | >230 °F |
| storage temp. | 2-8°C |
| solubility | Chloroform, Ethyl Acetate (Slightly) |
| form | Liquid |
| color | brown |
| Water Solubility | insoluble |
| BRN | 607374 |
| InChI | 1S/C10H10O/c11-10-7-3-5-8-4-1-2-6-9(8)10/h1-2,4,6H,3,5,7H2 |
| InChIKey | XHLHPRDBBAGVEG-UHFFFAOYSA-N |
| SMILES | O=C1CCCc2ccccc12 |
| CAS DataBase Reference | 529-34-0(CAS DataBase Reference) |
| NIST Chemistry Reference | 1(2H)-Naphthalenone, 3,4-dihydro-(529-34-0) |
| EPA Substance Registry System | 1,2,3,4-Tetrahydronaphthalen-1-one (529-34-0) |
| Safety Information |
| Hazard Codes | Xn |
| Risk Statements | 22-20/22-20/21/22 |
| Safety Statements | 23-24/25-36 |
| WGK Germany | 3 |
| RTECS | QK4375000 |
| TSCA | TSCA listed |
| HS Code | 29143900 |
| Storage Class | 10 - Combustible liquids |
| Hazard Classifications | Acute Tox. 4 Oral |
| Hazardous Substances Data | 529-34-0(Hazardous Substances Data) |
| Toxicity | LD50 orally in Rabbit: 810 mg/kg LD50 dermal Rabbit > 2200 mg/kg |
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