Sodium Methoxide #CAS124-41-4
Sodium methanolate is one of alkoxides that are generated by methanol. Its chemical formula is CH3ONa. It is strong base that is commonly used in organic synthesis.
Sodium methanolate is often stored in methanol, ethanol or the like alcohol solvent. It can generate suspension when it dissolves in ether. It can decompose into methanol and sodium hydroxide with water:CH3ONa + H2O→CH3OH + NaOH
Sodium methanolate product has two forms: solid and liquid. Solid is pure sodium methanolate. The liquid is methanol solution of sodium methanolate and the content of sodium methylate is 27.5% to 31%.
Liquid sodium methanolate is colorless or slightly yellow viscous liquid. It is sensitive to oxygen. It is flammable, explosive and easily hygroscopic. It is soluble in methanol and ethanol, and can decompose into methanol and sodium hydroxide with water. It decomposes at 126.6℃ in the air. It is not soluble in benzene and toluene. It is strong irritant and highly corrosive. Sodium methanolate can be used as condensing agent, strong alkaline catalyst and methoxy agent for the preparation of vitamin B1, vitamin A, sulfadiazine and other drugs. Few can be used in production of pesticides. It can also be used as catalyst in processing edible fats and oils (especially processing lard). It is used as analytical reagent.
Solid sodium methanolate is colorless amorphous powder. It is sensitive to oxygen, and it is flammable. It is soluble in methanol and ethanol, and can decompose into methanol and sodium hydroxide with water. It decomposes at 126.6℃ in the air. It is mainly used for the production of sulfa drugs, VB6 and VA. Sodium methylate is a kind of catalyst for organic synthesis. It can be used for the production of pesticides and oil processing industries.
Solid sodium methanolate and sodium methoxide methanol solution.
Sodium methylate is a kind of mature chemical products. It has several decades of production history in China. The overall price is high in the south than in the north. Its price is 4500 yuan/T in the southwest, and 4,000 yuan/T in Shandong. Its price changed little with the increase of methanol’s price in 2004. The profit of per ton of product is 500 to 700.
Application of Sodium Methoxide
Sodium methoxide can be used as alkaline condensing agent and catalyst in organic synthesis. It can be used to synthesize perfumes, dyes and the like. It is also the raw material of vitamin B1, A and sulfadiazine.
It can be used as condensing agent in organic synthesis and catalyst in edible oil process. It is also the important raw material to synthesize sulfadiazine, sulfamethoxazole, sulfa synergist and the like.
It is the main raw material used for medicine, pesticide. It is also used in dyes and chemical fiber industry.
Fatty transesterification catalyst. It can change the fat structure so that it is suitable for margarine. It must be removed in the final food.
It is mainly used as condensing agent, strong alkaline catalyst and methoxy agent. It can be used for the preparation of vitamin B1 and A, sulfadiazine and other drugs. And little can be used in the production of pesticides. It can also be used as the catalyst for processing edible fats and oils (especially processing lard). It can also be used as analytical reagent.
It is widely used in perfumes, dyes and other industries. It is mainly used as condensing agent, strong alkaline catalyst and methoxy agent for the preparation of vitamin B1 and A, sulfadiazine and other drugs. Little can be used in the production of pesticides. It can also be used as the catalyst for processing edible fats and oils (especially processing lard). It can also be used as analytical reagent.
It can be used as condensing agent in organic synthesis.
| Sodium Methoxide Chemical Properties |
| Melting point | -98 °C |
| Boiling point | 65 °C |
| density | 0.97 g/mL at 20 °C |
| bulk density | 500-600kg/m3 |
| vapor density | 1.1 (vs air) |
| vapor pressure | 50 mm Hg ( 20 °C) |
| refractive index | 1.3700 |
| Fp | 11 °C |
| storage temp. | Store at +5°C to +30°C. |
| solubility | Miscible with ethanol, methanol, fats and esters.Immiscible with hydrocarbons and organic solvents. |
| form | Powder |
| pka | 15.17[at 20 ℃] |
| Specific Gravity | 0.945 |
| color | clarity |
| PH | 11 (20°C, 20g/L in H2O) |
| explosive limit | 36% |
| Water Solubility | reacts |
| Sensitive | Moisture Sensitive |
| Hydrolytic Sensitivity | 8: reacts rapidly with moisture, water, protic solvents |
| Merck | 14,8643 |
| BRN | 3592982 |
| Exposure limits | ACGIH: Ceiling 2 mg/m3 OSHA: TWA 2 mg/m3 NIOSH: IDLH 10 mg/m3; Ceiling 2 mg/m3 |
| Dielectric constant | 1.5（Ambient） |
| Stability: | Stability Highly flammable. Reacts violently with water. Keep container dry. Incompatible with water, acids, chlorinated solvents. |
| InChI | 1S/CH3O.Na/c1-2;/h1H3;/q-1;+1 |
| InChIKey | WQDUMFSSJAZKTM-UHFFFAOYSA-N |
| SMILES | [Na+].C[O-] |
| LogP | -0.77 at 25℃ |
| CAS DataBase Reference | 124-41-4(CAS DataBase Reference) |
| NIST Chemistry Reference | Sodium methoxide(124-41-4) |
| EPA Substance Registry System | Sodium methoxide (124-41-4) |
| Safety Information |
| Hazard Codes | F,T,C |
| Risk Statements | 11-23/24/25-34-39/23/24/25-36/38-14-36/37/38-22-10 |
| Safety Statements | 8-16-26-43-45-7-36/37-7/8-36/37/39 |
| RIDADR | UN 1289 3/PG II/III (SODIUM METHYLATE SOLUTION in alcohol) |
| RIDADR | UN 1431 4.2/PG II (SODIUM METHYLATE) |
| WGK Germany | 1 |
| RTECS | PC3570000 |
| F | 9-21 |
| Autoignition Temperature | 878 °F |
| TSCA | TSCA listed |
| HazardClass | 4.2 |
| PackingGroup | II |
| HS Code | 29051900 |
| Storage Class | 4.2 - Pyrophoric and self-heating hazardous materials |
| Hazard Classifications | Acute Tox. 4 Oral Flam. Sol. 1 Met. Corr. 1 Self-heat. 1 Skin Corr. 1A |
| Hazardous Substances Data | 124-41-4(Hazardous Substances Data) |
| Toxicity | LD50 orally in Rabbit: 2037 mg/kg LD50 dermal Rat > 2000 mg/kg |
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