N,N-Diethyl-1,1,2,3,3,3-hexafluoropropylamine #CAS309-88-6
CAS Number:309-88-6
Chemical Formula:C7H11F6N
Synonyms:
1,1,2,3,3,3-HEXAFLUORO-1-DIETHYLAMINOPROPANE
N,N-DIETHYL-1,1,2,3,3,3-HEXAFLUOROPROPYLAMINE
SHIKAWA'S REAGENT
Appearance:Colorless to pale yellow transparent liquid at ambient temperature with slight amine odor; Density:1.230g/cm³@25℃, B.P.56-57℃/58mmHg, F.P.40℃; Moisture sensitive, slowly decomposes with water; Soluble in acetone, ether, toluene and most organic solvents; Color darkens to amber with prolonged storage.
MOQ (Minimum Order Quantity): 1 FCL (Full Container Load)
N,N-Diethyl-1,1,2,3,3,3-hexafluoropropylamine #CAS309-88-6
Fluorinated organic amine compound, fluorinating reagent, organic synthesis intermediate, special reagent for hydroxyl/carboxyl fluorination, pharmaceutical intermediate
UN2924, Class3 Flammable Liquid + Class8 Corrosive Liquid, Packing Group Ⅱ; GHS hazards: H226 Flammable liquid and vapor, H314 Causes severe skin burns and eye damage
HS Code:2921199090, other acyclic monoamines and their derivatives
Colorless to pale yellow transparent liquid at ambient temperature with slight amine odor; Density:1.230g/cm³@25℃, B.P.56-57℃/58mmHg, F.P.40℃; Moisture sensitive, slowly decomposes with water; Soluble in acetone, ether, toluene and most organic solvents; Color darkens to amber with prolonged storage.
GC analysis includes Et2NCF=CFCF3 (two isomers), both of which are active fluorinating agents.
Clear colorless to yellow liquid
Application of N,N-Diethyl-1,1,2,3,3,3-hexafluoropropylamine
Demonstrates utility in fluorination.7
Fluorinating agent.
Reactant for:
Friedel-Crafts type arylation of hydrofluorocarbons
Microbial hydroxylation of antibiotics
Electrochemical fluorination of trialkylamines and tetraalkylammonium salts
Fluorination of pyrethroides
Reactant for synthesis of:
γ-Hydroxy-α-fluoro-α-trifluoromethylcarboxamide
Florfenicol and thiamphenicol
| N,N-Diethyl-1,1,2,3,3,3-hexafluoropropylamine Chemical Properties |
| Boiling point | 56-57 °C (lit.) |
| density | 1.230 g/mL at 25 °C (lit.) |
| refractive index | 1.3460 |
| Fp | 56-57°C/58mm |
| storage temp. | Flammables area |
| solubility | soluble in Acetone,Ether |
| pka | 1.50±0.70(Predicted) |
| form | Liquid |
| color | Clear colorless to yellow |
| Specific Gravity | 1.230 |
| Merck | 14,5108 |
| InChI | 1S/C7H11F6N/c1-3-14(4-2)7(12,13)5(8)6(9,10)11/h5H,3-4H2,1-2H3 |
| InChIKey | BNTFCVMJHBNJAR-UHFFFAOYSA-N |
| SMILES | CCN(CC)C(F)(F)C(F)C(F)(F)F |
| CAS DataBase Reference | 309-88-6(CAS DataBase Reference) |
| EPA Substance Registry System | N,N-Diethyl-2H-perfluoropropanamine (309-88-6) |
| Safety Information |
| Hazard Codes | C |
| Risk Statements | 10-34 |
| Safety Statements | 16-26-36/37/39-45 |
| RIDADR | 3267 |
| WGK Germany | 3 |
| Hazard Note | Corrosive |
| HazardClass | 8 |
| PackingGroup | II |
| HS Code | 29211999 |
| Storage Class | 3 - Flammable liquids |
| Hazard Classifications | Flam. Liq. 3 Skin Corr. 1B |
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