Glyoxylic acid #CAS298-12-4
CAS Number:298-12-4
Chemical Formula:C2H2O3
Synonyms:
alpha-ketoaceticacid
oxo-aceticaci
Glyoxalic acid 40% 50%
Appearance:Colorless to Light Orange to Yellow Clear Liquid
MOQ (Minimum Order Quantity): 1 FCL (Full Container Load)
Glyoxylic acid #CAS298-12-4
Glyoxylic acid, also known as formic acid, hydrated glyoxylic acid, or oxoacetic acid, has the chemical formula C₂H₂O₃. It is the simplest aldehyde acid, found in unripe fruits, tender green leaves, and sugar beets. When crystallized from water, it forms a monoclinic crystal (containing half water of crystallization). Its relative molecular mass is 70.04. Its melting point is 98°C. It has an unpleasant odor, is a highly corrosive acid, and is extremely hygroscopic; when exposed to air, it can form a paste. It is slightly soluble in ethanol, ether, and benzene, and readily soluble in water. Its aqueous solution is very stable and does not deteriorate in air. In aqueous solution, it exists in its hydrated form. It reacts with most metals except stainless steel. It exhibits properties of both acids and aldehydes. It can undergo addition reactions with sodium bisulfite or hydrocyanic acid, react with hydroxylamine or phenylhydrazine to form oximes or hydrazones, undergo the silver mirror reaction, the Cannizzaro reaction, and can also form carboxylates and esters.
Application of Glyoxylic acid
Glyoxalic acid can be used in the synthesis of a variety of reactions.
Glyoxylic acid is used in Hopkins Cole reaction, which is used in the detection of tryptophan in proteins.
It reacts with phenol to get 4-hydroxymandelic acid, which on further reaction with ammonia gives hydroxyphenylglycine, as a precursor to the drug amoxicillin.
It is also used as a starting material for the preparation of 4-hydroxyphenylacetic acid, which is used to get atenolol.
| Glyoxylic acid Chemical Properties |
| Melting point | -93°C |
| Boiling point | 111°C |
| density | 1.33 g/mL at 20 °C |
| vapor pressure | 14hPa at 19.85℃ |
| refractive index | n |
| Fp | 111°C |
| storage temp. | Store below +30°C. |
| solubility | Miscible with ethanol. Slightly miscible with ether and benzene. Immiscible with esters. |
| pka | 3.18(at 25℃) |
| form | clear liquid |
| color | Colorless to Light orange to Yellow |
| PH | 0.3 (19.5°C in H2O) |
| Water Solubility | miscible |
| Merck | 14,4511 |
| BRN | 741891 |
| Henry's Law Constant | 1.1×102 mol/(m3Pa) at 25℃, Burkholder et al. (2019) |
| Cosmetics Ingredients Functions | BUFFERING ANTISTATIC HAIR WAVING OR STRAIGHTENING |
| InChI | 1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5) |
| InChIKey | HHLFWLYXYJOTON-UHFFFAOYSA-N |
| SMILES | OC(=O)C=O |
| LogP | -0.930 (est) |
| CAS DataBase Reference | 298-12-4(CAS DataBase Reference) |
| NIST Chemistry Reference | Acetic acid, oxo-(298-12-4) |
| EPA Substance Registry System | Acetic acid, 2-oxo- (298-12-4) |
| Safety Information |
| Hazard Codes | C,Xi |
| Risk Statements | 34-43-41 |
| Safety Statements | 26-36/37/39-45-37/39-24 |
| RIDADR | UN 3265 8/PG 2 |
| WGK Germany | 1 |
| RTECS | MD4550000 |
| TSCA | TSCA listed |
| HazardClass | 8 |
| PackingGroup | III |
| HS Code | 29183000 |
| Storage Class | 8A - Combustible corrosive hazardous materials |
| Hazard Classifications | Eye Dam. 1 Met. Corr. 1 Skin Sens. 1 |
| Hazardous Substances Data | 298-12-4(Hazardous Substances Data) |
| Toxicity | rat,LDLo,intramuscular,250mg/kg (250mg/kg),Bolletino della Societe Italiana di Biologia Sperimentale. Vol. 36, Pg. 1937, 1960. |
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