Eugenol #CAS97-53-0
CAS Number:97-53-0
Chemical Formula:C10H12O2
Synonyms:
PHENOL, 4-ALLYL-2-METHOXY
4-allyl-2-methoxyphenol (eugenol)
4-Allylcatechol-2-methyl ether
Appearance:Clear Pale Yellow to Yellow Liquid
MOQ (Minimum Order Quantity): 1 FCL (Full Container Load)
Eugenol #CAS97-53-0
The scientific name for eugenol is 4-allyl-2-methoxyphenol. Some data about it are as follows: molecular formula C10H12O2; molecular weight 164.21; boiling point 253 ℃; melting point-9.2 ~-9.1℃; relative density d2525 1.053~1.064; refractive index nD20 1.538~1.542. It is miscible with alcohol, ether, chloroform and volatile oil. What’s more, it is slightly soluble in water, and soluble in acetic acid and caustic solution. It gradually darkens and thickens in the air. Iron, zinc and other metal ions could catalyze its oxidation. So we should store it below 25 ℃, and protect it from light. Eugenol could make the red litmus and ferric chloride ethanol solution blue. It is present in the clove oil (90%), clove basil oil (about 60%), violet flower oil (about 20%), cinnamon leaf oil, lauric oil, camphor oil, acacia oil and citronella oil. It can be used as fixative and modifier for woody and oriental essence in the spice. It is the main essence for preparation of clove and carnation flavor. It is also often used in the mint, nut and spicy food flavor and tobacco flavor. It can also be used to synthesize vanillin. It is applied for medical and health products and dental hygiene. Eugenol is available in the United States FEMA2467, and it is approved for food by US FDA.
Application of Eugeno
eugenol is a botanical fraction. It is anti-bacterial, anti-inflammatory, and pain relieving. It can also be used as a local, topical anesthetic and antiseptic. In a cosmetic formulation, it can mask odor or provide fragrance. eugenol is a yellow, oily liquid and is generally associated with clove oil. However, it is also found in nutmeg, cinnamon, and bay leaf.
Eugenol is a flavoring obtained from clove oil and also found in car- nation and cinnamon leaves. it is a stable, light yellow-green liquid of clove odor. it is slightly soluble in water and miscible in alcohol. it should be stored in glass or tin, avoiding iron containers. it is used in spice oils for application in condiments and meats at 100–200 ppm and in baked goods and candy at approximately 30 ppm.
Eugenol is a dental compound which shows cytotoxicity to human oral squamous cell carcinoma and oral cells. When glucosylated, this compound exhibits anti-inflammatory activity.
| Eugenol Chemical Properties |
| Melting point | -12--10 °C (lit.) |
| Boiling point | 254 °C (lit.) |
| density | 1.067 g/mL at 25 °C (lit.) |
| vapor pressure | <0.1 hPa (25 °C) |
| FEMA | 2467 | EUGENOL |
| refractive index | n |
| Fp | >230 °F |
| storage temp. | 2-8°C |
| solubility | 2.46g/l |
| form | Liquid |
| pka | pKa 9.8 (Uncertain) |
| color | Clear pale yellow to yellow |
| Odor | at 10.00 % in dipropylene glycol. sweet spicy clove woody |
| Odor Type | spicy |
| biological source | synthetic |
| Water Solubility | slightly soluble |
| Sensitive | Air Sensitive |
| Merck | 14,3898 |
| JECFA Number | 1529 |
| BRN | 1366759 |
| Henry's Law Constant | 9.2×100 mol/(m3Pa) at 25℃, McFall et al. (2020) |
| Dielectric constant | 6.1（18℃） |
| Stability: | Stable. Combustible. Incompatible with strong oxidizing agents. |
| Major Application | agriculture cleaning products cosmetics environmental flavors and fragrances food and beverages personal care |
| Cosmetics Ingredients Functions | DENATURANT TONIC PERFUMING |
| InChI | 1S/C10H12O2/c1-3-4-8-5-6-9(11)10(7-8)12-2/h3,5-7,11H,1,4H2,2H3 |
| InChIKey | RRAFCDWBNXTKKO-UHFFFAOYSA-N |
| SMILES | COc1cc(CC=C)ccc1O |
| LogP | 1.83 at 30℃ |
| CAS DataBase Reference | 97-53-0(CAS DataBase Reference) |
| NIST Chemistry Reference | Eugenol(97-53-0) |
| IARC | 3 (Vol. 36, Sup 7) 1987 |
| EPA Substance Registry System | Eugenol (97-53-0) |
| Safety Information |
| Hazard Codes | Xn,Xi |
| Risk Statements | 22-36/37/38-42/43-38-40-43-36/38 |
| Safety Statements | 26-36-24/25-23-36/37 |
| RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution |
| WGK Germany | 1 |
| RTECS | SJ4375000 |
| F | 10-23 |
| TSCA | TSCA listed |
| HS Code | 29095090 |
| Storage Class | 10 - Combustible liquids |
| Hazard Classifications | Eye Irrit. 2 Skin Sens. 1 |
| Hazardous Substances Data | 97-53-0(Hazardous Substances Data) |
| Toxicity | LD50 in rats, mice (mg/kg): 2680, 3000 orally (Hagan) |
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