DIFLUOROACETIC ANHYDRIDE #CAS401-67-2

DIFLUOROACETIC ANHYDRIDE #CAS401-67-2

Difluoroacetic anhydride (CAS: 401-67-2) is a colorless, transparent liquid with the molecular formula C₄H₂F₄O₃. As a key fluorinating agent and organic synthesis intermediate, it is commonly used in pharmaceutical and pesticide research and development, and also in the synthesis of difluoroacetic acid esters. This substance is highly irritating and corrosive, and must be stored in a strictly moisture-proof and light-protected environment.

1. Difluoroacetic acid reacts with phosphorus pentoxide. Distillation yields difluoroacetic anhydride.
2. More difluoroacetic acid is added to the residue from step 1. Distillation gives a mixture containing the anhydride.
3. Difluoroacetic acid and methanol are added to the residue from step 2. Distillation yields methyl difluoroacetate.
4. The mixture from step 2 is reacted with phosphorus pentoxide. Distillation yields more difluoroacetic anhydride.

Application of DIFLUOROACETIC ANHYDRIDE

Difluoroacetic anhydride is mainly used as an acylation reagent in organic synthesis to introduce difluoroacetyl groups. Difluoroacetate is mainly used as an intermediate in pesticides, pharmaceuticals, and fluorine-containing fine chemicals, and can also be used as a solvent in lithium battery electrolytes.

Product Name:	DIFLUOROACETIC ANHYDRIDE
Synonyms:	2,2-difluoroacetic acid (2,2-difluoro-1-oxoethyl) ester;2,2-Difluoro-acetic acid 1,1'-anhydride;1,1,5,5-Tetrafluoro-3-oxapentan-2,4-dione;DIFLUOROACETIC ANHYDRIDE;DIFLUOROACETIC ACID ANHYDRIDE;DifluoroaceticAnhydride>;Acetic acid,2,2-difluoro-, 1,1'-anhydride;2,2-difluoroacetic anhydride
CAS:	401-67-2
MF:	C4H2F4O3
MW:	174.05
EINECS:	200-258-5
Product Categories:
Mol File:	401-67-2.mol

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