2-Bromo-4-methylaniline #CAS583-68-6
CAS Number:583-68-6
Chemical Formula:C7H8BrN
Synonyms:
2-Bromo-4-methylbenzenamine
2-Bromo-4-methylanline
2-bromo-4-methyl-benzenamin
Appearance:Dark Yellow to Dark Beige Oil
MOQ (Minimum Order Quantity): 1 FCL (Full Container Load)
2-Bromo-4-methylaniline #CAS583-68-6
2-Bromo-p-toluidine, with the chemical formula C7H8BrN, molecular weight 186.05, and CAS Registry number 583-68-6, is a colorless liquid with a melting point of 26°C, a boiling point of 240°C, a density of 1.498 g/cm³, and a refractive index of 1.6020. It is miscible with ethanol and ether, but insoluble in water.
As an organic synthesis intermediate, it is synthesized from p-toluidine through acetylation, bromination, hydrolysis, and alkali treatment, with a yield of 51-57%. Its hazard class is 6.1, transport number UN 2810, and risk terms cover inhalation, skin contact, and ingestion toxicity. Hazard symbols include H301/H311/H331. Upstream and downstream products involve raw materials such as 4-methylacetanilide and various downstream derivatives.
Application of 2-Bromo-4-methylaniline
2-Bromo-4-methylaniline has been used in the synthesis of iminophosphoranes.
| 2-Bromo-4-methylaniline Chemical Properties |
| Melting point | 14-16 °C (lit.) |
| Boiling point | 240 °C (lit.) |
| density | 1.5 g/mL at 25 °C (lit.) |
| refractive index | n |
| Fp | >230 °F |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | Chloroform (Slightly) |
| form | Oil |
| pka | 2.97±0.10(Predicted) |
| color | Dark Yellow to Dark Beige |
| Specific Gravity | 1.500 |
| Water Solubility | Insoluble in water. |
| BRN | 1931711 |
| Stability: | Air Sensitive |
| InChI | 1S/C7H8BrN/c1-5-2-3-7(9)6(8)4-5/h2-4H,9H2,1H3 |
| InChIKey | UVRRJILIXQAAFK-UHFFFAOYSA-N |
| SMILES | Cc1ccc(N)c(Br)c1 |
| CAS DataBase Reference | 583-68-6(CAS DataBase Reference) |
| NIST Chemistry Reference | Benzenamine, 2-bromo-4-methyl-(583-68-6) |
| EPA Substance Registry System | Benzenamine, 2-bromo-4-methyl- (583-68-6) |
| Safety Information |
| Hazard Codes | T,Xi,Hazard |
| Risk Statements | 23/24/25-36/37/38-33-20/21/22 |
| Safety Statements | 36/37/39-45-26 |
| RIDADR | UN 2810 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | XU4300000 |
| Hazard Note | Irritant/Toxic |
| TSCA | TSCA listed |
| HazardClass | 6.1 |
| PackingGroup | III |
| HS Code | 29214300 |
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
| Hazard Classifications | Acute Tox. 3 Dermal Acute Tox. 3 Inhalation Acute Tox. 3 Oral |
| 2-Bromo-4-methylaniline Usage And Synthesis |
| Chemical Properties | clear light yellow to brown liquid |
| Uses | 2-Bromo-4-methylaniline has been used in the synthesis of iminophosphoranes. |
| General Description | 2-Bromo-4-methylaniline participates in palladium catalyzed selective amination of 3-bromoquinoline to yield 3-(2-bromo-4-methylphenylamino) quinoline. It reacts with ethyl and methyl imidazo[1,2-a]pyridine-2-carboxylates in the presence of Me3Al to form amide. |
| 2-Bromo-4-methylaniline Preparation Products And Raw materials |
| Raw materials | Sodium sulfite-->p-Acetotoluidide-->N-Acetyl-p-toluidine -->Silanamine, 1,1,1-trimethyl-N-(4-methylphenyl)--->methyl N-(2-bromo-4-methylphenyl)carbamate-->2-BROMO-4-METHYLANILINE HYDROCHLORIDE-->2-BroMo-4-Methyl-1-nitro-benzene-->2-Bromo-4-methylphenylboronic acid-->2-BROMO-N-METHYLANILINE 95 |
| Preparation Products | 3-Bromotoluene-->2-BROMO-4-METHYLBENZONITRILE-->5-Methylindole-->2-Bromo-4-methylphenol-->2'-BROMO-4'-METHYLACETANILIDE-->5-METHYLINDOLE-3-CARBOXYLIC ACID METHYL ESTER-->5-METHYL-2-PHENYLINDOLE-->2-Chloro-6-methylbenzothiazole-->2-Amino-5-Methyl-Benzonitrile-->2-Bromo-4-methylbenzaldehyde |
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