1-Phenoxy-2-propanol #CAS770-35-4
1-Phenoxy-2-propanol (PP), a gycol ether, can be synthesized by reacting propylene oxide with phenol in the presence of Al2O3-MgO/Fe3O4 catalyst. The influence of its anesthetic property on gastropods has been analyzed. Its degradation by microorganisms in different soil types has been investigated.
1-Phenoxy-2-propanol (PP) does not cause skin irritation or sensitization. However, it may induce mucosal irritation. The pregnant Himalayan rabbits were orally administered 0, 60, 180, and 540mg/kg/day of PP during organogenesis (7–19 days of pregnancy). LOAEL (Lowest Observed Adverse Effect Level) for maternal toxicity was assessed at 540mg/kg/day based on weight loss and apathy. In addition, LOAEL for developmental toxicity was 540mg/kg/day, and NOAEL (No Observed Adverse Effect Level) was assessed at 180mg/kg/day. The other study reported that NOAEL for maternal toxicity of PP orally treated to pregnant Wistar rats was 40mg/kg/day, and NOAEL for developmental toxicity of PP was 160mg/kg/day.
Application of 1-Phenoxy-2-propanol #CAS770-35-4
High-boiling solvent, bactericidal agent, fixa- tive for soaps and perfumes, intermediate for plas- ticizers.
1-Phenoxy-2-propanol is a useful synthetic intermediate. It was used in the preparation of acylarylthiocarbamates as nonnucleoside reverse transcriptase inhibitors.
1-Phenoxy-2-propanol (PP) is used as a preservative in cosmetics. PP is currently permitted for up to 1% in cosmetic formulations in Korea and Europe. In addition to its cosmetic uses, PP is used as a solvent for mixing water and organic components in paints, coatings, and films. It is used as an ink solvent for industrial paints, ballpoint pens, stamp pads, and paint removers. The exposure range is broad since PP is used in various industrial paints and cosmetic
| 1-Phenoxy-2-propanol Chemical Properties |
| Melting point | 11 °C |
| Boiling point | 243 °C (lit.) |
| density | 1.064 g/mL at 20 °C (lit.) |
| vapor pressure | 1Pa at 20℃ |
| refractive index | n |
| Fp | >230 °F |
| storage temp. | Refrigerator |
| solubility | water: soluble15.1g/L at 20°C |
| form | Oil |
| pka | 14.43±0.20(Predicted) |
| color | Clear Colourless |
| Specific Gravity | 1.051 |
| Water Solubility | 15.1g/L at 20℃ |
| BRN | 1941356 |
| Henry's Law Constant | 3.4×102 mol/(m3Pa) at 25℃, HSDB (2015) |
| Stability: | Stable. Flammable. Incompatible with strong oxidizing agents. |
| Cosmetics Ingredients Functions | PRESERVATIVE SOLVENT |
| InChI | 1S/C9H12O2/c1-8(10)7-11-9-5-3-2-4-6-9/h2-6,8,10H,7H2,1H3 |
| InChIKey | IBLKWZIFZMJLFL-UHFFFAOYSA-N |
| SMILES | CC(O)COc1ccccc1 |
| LogP | 1.41 at 24.1℃ |
| CAS DataBase Reference | 770-35-4(CAS DataBase Reference) |
| NIST Chemistry Reference | 1-Phenoxy-2-propanol(770-35-4) |
| EPA Substance Registry System | 1-Phenoxy-2-propanol (770-35-4) |
| Safety Information |
| Hazard Codes | Xi |
| Risk Statements | 36 |
| Safety Statements | 23-26 |
| WGK Germany | 1 |
| RTECS | UB8886500 |
| TSCA | TSCA listed |
| HS Code | 29094990 |
| Storage Class | 10 - Combustible liquids |
| Hazard Classifications | Eye Irrit. 2 |
| Hazardous Substances Data | 770-35-4(Hazardous Substances Data) |
| Toxicity | LD50 orl-rat: 2830 mg/kg NTIS** OTS0539745 |
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