3-Aminopyrazole #CAS1820-80-0
CAS Number:1820-80-0
Chemical Formula:C3H5N3
Synonyms:
3-AMINO-1H-PYRAZOLE
AKOS B007331
pyrazol-3-ylamine
Appearance:White to Light Yellow Oily Liquid or Crystalline Low Melting Solid
MOQ (Minimum Order Quantity): 1 FCL (Full Container Load)
3-Aminopyrazole #CAS1820-80-0
3-Aminopyrazole is an organic intermediate that can be obtained by reducing nitropyrazole, or by first cyclizing ethyl ethoxymethylene cyanoacetate with hydrazine hydrate to prepare 3(5)-aminopyrazole-4-carboxylic acid, and then decarboxylating it.
Application of 3-Aminopyrazole
Employed in a one-pot synthesis of pyrazolopyrimidines.1
3-Aminopyrazole was used in the spectroscopic characterization of ferrocenoyl peptides via 1H-NMR spectroscopy. It was also used in the synthesis of:
symmetrical dialkylpyrazolo[1,5-a]pyrimidines via condensation with symmetrical β-diketones
3,4-annelated coumarins
heterocyclic compounds of pharmaceutical interest
pyrazolopyrimidines
3-Aminopyrazole is used in the preparation of heterocyclic compounds of pharamaceutical interest
| 3-Aminopyrazole Chemical Properties |
| Melting point | 34-37 °C (lit.) |
| Boiling point | 218 °C/122 mmHg (lit.) |
| density | 1.0248 (rough estimate) |
| refractive index | 1.5060 (estimate) |
| Fp | >230 °F |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| solubility | soluble in Methanol |
| pka | 15.28±0.10(Predicted) |
| form | Oily Liquid or Crystalline Low Melting Solid |
| color | White to light yellow |
| Sensitive | Air & Light Sensitive |
| BRN | 1618 |
| InChI | 1S/C3H5N3/c4-3-1-2-5-6-3/h1-2H,(H3,4,5,6) |
| InChIKey | JVVRJMXHNUAPHW-UHFFFAOYSA-N |
| SMILES | Nc1cc[nH]n1 |
| CAS DataBase Reference | 1820-80-0(CAS DataBase Reference) |
| NIST Chemistry Reference | 3(5)-aminopyrazole(1820-80-0) |
| Safety Information |
| Hazard Codes | C,Xi |
| Risk Statements | 22-34-36/37/38 |
| Safety Statements | 26-36/37/39-45-27 |
| RIDADR | UN 3263 8/PG 2 |
| WGK Germany | 3 |
| F | 8-10-23 |
| Hazard Note | Corrosive |
| HazardClass | IRRITANT |
| HazardClass | 8 |
| PackingGroup | Ⅱ |
| HS Code | 29331990 |
| Storage Class | 8A - Combustible corrosive hazardous materials |
| Hazard Classifications | Acute Tox. 4 Oral Eye Dam. 1 Skin Corr. 1B |
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