2-Methyl-4-isothiazolin-3-one hydrochloride CAS：26172-54-3
2‑Methyl‑4‑isothiazolin‑3‑one hydrochloride (CAS 26172‑54‑3) is a water‑soluble solid compound with antimicrobial and antifungal properties. It is frequently employed in scientific investigations to assess its cytotoxic impacts on bronchial epithelial cells and its role in neural development. As a stabilized derivative of the biocidal substance methylisothiazolinone (MIT), it exerts its effects by disrupting protein synthesis, and is widely utilized as a preservative across industrial uses and personal care formulations.
Core Characteristics
Research Applications
Serves as a cytotoxic substance in laboratory studies, commonly applied in research on cell apoptosis, for instance in experiments involving BEAS-2B cells.
2-Methyl-4-isothiazolin-3-one Hydrochloride is an isothiazolinone based biocide and preservative used in personal care products. It is also implicated as an allergen. It is also used for controlling microbial growth in water-containing solution.
Safety Warnings
Typical Uses
Antimicrobial Substance: Utilized in scientific research for its bactericidal and fungicidal capabilities.
Industrial Preservative: Widely added to water-based products including adhesives to inhibit spoilage and deterioration.
Analytical Reference Material: Used as a standard in HPLC and other chromatographic methods for product detection and analysis.
Safety & Handling Guidelines
Allergenic Risk: As a highly effective biocide, it may trigger contact dermatitis upon exposure.
Operational Safety: Due to its inherent biocidal properties, cautious operation and proper protection are required during use.
| 2-Methyl-4-isothiazolin-3-one hydrochloride Chemical Properties |
| Melting point | 165-170° |
| density | 1.551 at 21℃ |
| vapor pressure | 0.777-1Pa at 20-25℃ |
| storage temp. | 2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| color | White to Off-White |
| BRN | 3993054 |
| Stability: | Hygroscopic |
| Major Application | microbiology |
| InChI | InChI=1S/C4H5NOS.ClH/c1-5-4(6)2-3-7-5;/h2-3H,1H3;1H |
| InChIKey | SJXPQSRCFCPWQQ-UHFFFAOYSA-N |
| SMILES | O=C1C=CSN1C.Cl |
| LogP | -0.44 at 20℃ and pH2 |
| Surface tension | 71.3mN/m at 1g/L and 20℃ |
| CAS DataBase Reference | 26172-54-3(CAS DataBase Reference) |
| EPA Substance Registry System | 3(2H)-Isothiazolone, 2-methyl-, hydrochloride (26172-54-3) |
| Safety Information |
| Hazard Codes | C |
| Risk Statements | 34-42/43 |
| Safety Statements | 26-36/37/39-45 |
| RIDADR | UN 1759 8/PG 2 |
| WGK Germany | 3 |
| TSCA | TSCA listed |
| HazardClass | 8, 6.1 |
| HS Code | 2934100090 |
| Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials |
| Hazard Classifications | Acute Tox. 3 Oral Aquatic Acute 1 Aquatic Chronic 1 Eye Dam. 1 Skin Corr. 1A Skin Sens. 1 |
